Respuesta de schizosaccharomyces pombe a la desestabilización de microtúbulos interfásicos

  1. Romero Balestra, Fernando
unter der Leitung von:
  1. Juan Jiménez Doktorvater

Universität der Verteidigung: Universidad Pablo de Olavide

Fecha de defensa: 25 von Juni von 2009

Gericht:
  1. Jaime Correa Bordes Präsident/in
  2. Rafael Daga Sekretär
  3. José Cansado Vizoso Vocal
  4. Juan Ignacio Mata Monteagudo Vocal
  5. María de la Cruz Muñoz Centeno Vocal
Fachbereiche:
  1. Biología Molecular e Ingeniería Bioquímica

Art: Dissertation

Teseo: 303789 DIALNET lock_openTESEO editor

Zusammenfassung

Microtubules assume a variety of structures throughout the different stages of the cell cycle. Ensuring the correct assembly of such structures is essential to guarantee cell division. During mitosis, it is well established that the spindle assembly checkpoint monitors the correct attachment of sister chromatids to the mitotic spindle. However, the role that microtubule cytoskeleton integrity plays for cell-cycle progression during interphase is uncertain. Here we describe the existence of a mechanism, independent of the mitotic checkpoint, that delays entry into mitosis in response to G(2)-phase microtubule damage. Disassembly of the G(2)-phase microtubule array leads to the stabilization of the universal mitotic inhibitor Wee1, thus actively delaying entry into mitosis via inhibitory Cdc2 Tyr15 phosphorylation.