Diferenciación de células madre como modelo experimental de terapia en enfermedades prevalentesosteoartritis y patología cardiovascular

Résumé

It is broadly known the limited regeneration capacity of cartilage and cardiac tissue. The main goal of the present study was to develop strategies to direct cell differentiation toward cardiac and cartilage linage with potential to repair and/or regenerate the damage tissue. Here we have studied the potential differentiation capacity of four different cell sources: i) human adipose derived stem cells (hASCs) isolated from lipoaspirates; ii) hASCs obtained from infrapatellar fat pad (IFPSCs) of patients with osteoarthritis (OA), iii) endothelial progenitor cells (EPCs) derived from umbilical cord blood (UCB) and iv) EPCs isolated from peripheral blood (PB) of patients suffering from acute myocardial infarction (AMI). In conclusion, we have implemented novel strategies to direct cell differentiation. The finding included in this study could represent a potential therapeutic approach in cardiovascular diseases and osteochondral injuries.