Innovative compounds to battle multiresistanceto antibioticsUse of PVA-tannic acid nanoparticles to inhibit staphylococcus pseudointermedius growth
- Guillermo Martínez
- María Pérez-Aranda
- Manuel Merinero
- Belén Begines
- Tamara Ortiz
- Salvadora Navarro
- Raúl Aguilera-Velázquez
- María-Jesús Martín
- Ignacio Rodríguez
- Eloisa Pajuelo
- Ana-Paula Zaderenko
- Ana Alcudia
- Ana M. Beltrán Custodio (coord.)
- Manuel Félix Ángel (coord.)
Verlag: 3ciencias
ISBN: 978-84-122093-4-1
Datum der Publikation: 2021
Seiten: 45-48
Art: Buch-Kapitel
Zusammenfassung
Antibiotic resistance is an increasing public health problem that affects numerouspathogens, including Staphylococcus pseudintermedius, which has a high prevalenceof methicillin resistance and can be easily transmitted to humans. Nowadays, thescientific community is developing new compounds that not only improve classictherapies in fighting antibiotic resistances but also prevent its appearance, essentialto maintain health protection. The main objective of the present study is tosynthesize tannic acid and polyvinyl alcohol nanoparticles and to determine theirpotential as growth inhibitors for S. pseudintermedius, to be considered a potentialalternative therapy. The study includes diameter and Z-potential measurementsfor nanoparticles characterization and antimicrobial effect assays with differentnanoparticles concentrations. MIC90 is determined as 112 μg/mL. Nonetheless,further studies to identify the underlying action mechanisms of these nanoparticlesare going on in our group.