La nutrición y el ejercicio como factores a considerar en el Síndrome de Down

  1. María Pilar Hernández Barrera
  2. Eduardo Domínguez del Toro
Journal:
Revista de Discapacidad, Clínica y Neurociencias: (RDCN)

ISSN: 2341-2526

Year of publication: 2023

Volume: 10

Issue: 1

Pages: 39-50

Type: Article

More publications in: Revista de Discapacidad, Clínica y Neurociencias: (RDCN)

Abstract

Down syndrome (DS) is one of the most common genetic pathologies that alter the human body from a neuronal aspect to a cardio-metabolic aspect. It is a disease that in summary produces an alteration of lipids, sugars, and proteins in the body, so its affectation is multiorganic. The design of this review is based on the idea that diet and lifestyle, together with physical exercise, can positively alter the effects of the disease on the body, so the aim of the review is to search for a relationship between healthy lifestyle and an improvement in the quality of life of people with DS. As a method it has been used the bibliographic review of several articles, clinical cases and original scientific studies related to diet, exercise and lifestyle in individuals affected by DS, taking as inclusion criteria those that mentioned nutrition, physical exercise and DS, and as the main exclusion criterion, those articles that did not mention any of these factors or did not relate them to each other. This review has shown facing results, from studies that show us that there is not enough scientific rigor to declare that lifestyle can influence DS, to studies that, for the most part, show us the opposite, with improvements in the level of health of the participants, which reduces the risk factors that are associated with decreasing the life expectancy of these individuals.

Bibliographic References

  • Bull MJ. Down Syndrome. New England Journal of Medicine [Internet]. 2020;382(24):2344–52. https://doi.org/10.1056/NEJMra1706537
  • Jaruratanasirikul S, Limpitikul W, Dissaneevate P, Booncharoen P, Tantichantakarun P. Comorbidities in Down syndrome livebirths and health care intervention: an initial experience from the birth defects registry in Southern Thailand. World Journal of Pediatrics [Internet]. 2017;13(2):152–7. https://doi.org/10.1007/s12519-016-0093-z
  • Bull MJ, Saal HM, Braddock SR, Enns GM, Gruen JR, Perrin JM, et al. Clinical report - Health supervision for children with Down syndrome. Vol. 128, Pediatrics. American Academy of Pediatrics; 2011. p. 393–406. https://doi.org/10.1542/peds.2011-1605
  • Normand J, Sassolas F, Bozio A, Jocteur-Monrozier D, André M. [Cardiopathies in trisomy 21. Therapeutic indications]. Arch Mal Coeur Vaiss. 1981 Dec;74(12):1427–36. PMID: 6460481.
  • Lagan N, Huggard D, Mc Grane F, Leahy TR, Franklin O, Roche E, et al. Multiorgan involvement and management in children with Down syndrome. Acta Paediatr. 2020 Jun;109(6):1096–111. https://doi.org/10.1111/apa.15153
  • Versacci P, di Carlo D, Digilio MC, Marino B. Cardiovascular disease in Down syndrome. Curr Opin Pediatr. 2018 Oct;30(5):616–22. 10.1097/MOP.0000000000000661.
  • Mortimer GL, Gillespie KM. Early Onset of Autoimmune Diabetes in Children with Down Syndrome—Two Separate Aetiologies or an Immune System Pre-Programmed for Autoimmunity? Curr Diab Rep. 2020 Sep 25;20(9):47. https://doi.org/10.1007/s11892-020-01318-8
  • Karlsson B, Gustafsson J, Hedov G, Ivarsson SA, Anneren G. Thyroid dysfunction in Down’s syndrome: relation to age and thyroid autoimmunity. Arch Dis Child. 1998 Sep 1;79(3):242–5. http://dx.doi.org/10.1136/adc.79.3.242
  • Whooten R, Schmitt J, Schwartz A. Endocrine manifestations of Down syndrome. Current Opinion in Endocrinology & Diabetes and Obesity. 2018 Feb;25(1):61–6. 10.1097/MED.0000000000000382
  • Butler AE, Sacks W, Rizza RA, Butler PC. DownSyndrome-Associated Diabetes Is Not Due To a Congenital Deficiency in β Cells. J Endocr Soc. 2017 Jan 1;1(1):39–45. https://doi.org/10.1210/js.2016-1042
  • Kota S, Kota S, Jammula S, Tripathy P. Type 2 diabetes mellitus: An unusual association with Down′s syndrome. Indian J Hum Genet. 2013;19(3):358. 10.4103/0971-6866.120818
  • Rachidi M, Lopes C. Mental retardation and associated neurological dysfunctions in Down syndrome: A consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways. European Journal of Paediatric Neurology. 2008 May;12(3):168–82. https://doi.org/10.1016/j.ejpn.2007.08.010
  • Santoro JD, Pagarkar D, Chu DT, Rosso M, Paulsen KC, Levitt P, et al. Neurologic complications of Down syndrome: a systematic review. J Neurol. 2021 Dec 12;268(12):4495–509. https://doi.org/10.1007/s00415-020-10179-w
  • Fernández de la Puente M, Hernández-Alonso P, Canudas S, Marti A, Fitó M, Razquin C, et al. Modulation of Telomere Length by Mediterranean Diet, Caloric Restriction, and Exercise: Results from PREDIMED-Plus Study. Antioxidants. 2021 Oct 12;10(10):1596. https://doi.org/10.3390/antiox10101596
  • Fernandes J, Arida RM, Gomez-Pinilla F. Physical exercise as an epigenetic modulator of brain plasticity and cognition. Neurosci Biobehav Rev. 2017 Sep;80:443–56. https://doi.org/10.1016/j.neubiorev.2017.06.012
  • Magge SN, Zemel BS, Pipan ME, Gidding SS, Kelly A. Cardiometabolic Risk and Body Composition in Youth With Down Syndrome. Pediatrics. 2019 Aug 1;144(2). https://doi.org/10.1542/peds.2019-0137
  • Bertapelli F, Pitetti K, Agiovlasitis S, Guerra-Junior G. Overweight and obesity in children and adolescents with Down syndrome—prevalence, determinants, consequences, and interventions: A literature review. Res Dev Disabil. 2016 Oct;57:181–92. https://doi.org/10.1016/j.ridd.2016.06.018
  • Fujiura G. Predictors of BMI among adults with down syndrome: The social context of health promotion. Res Dev Disabil. 1997 Aug;18(4):261–74. https://doi.org/10.1016/S0891-4222(97)00008-5
  • Jobling A, Cuskelly M. Young people with Down syndrome: A preliminary investigation of health knowledge and associated behaviours. J Intellect Dev Disabil. 2006 Dec 10;31(4):210–8. https://doi.org/10.1080/13668250600999186
  • Nordstrøm M, Hansen BH, Paus B, Kolset SO. Accelerometer-determined physical activity and walking capacity in persons with Down syndrome, Williams syndrome and Prader–Willi syndrome. Res Dev Disabil. 2013 Dec;34(12):4395–403. https://doi.org/10.1016/j.ridd.2013.09.021
  • Nordstrøm M, Paus B, Andersen LF, Kolset SO. Dietary aspects related to health and obesity in Williams syndrome, Down syndrome, and Prader–Willi syndrome. Food Nutr Res. 2015 Jan 19;59(1):25487. http://dx.doi.org/10.3402/fnr.v59.25487
  • Bathgate K, Sherriff J, Leonard H, Dhaliwal S, Delp E, Boushey C, et al. Feasibility of Assessing Diet with a Mobile Food Record for Adolescents and Young Adults with Down Syndrome. Nutrients. 2017 Mar 13;9(3):273. https://doi.org/10.3390/nu9030273
  • Ptomey LT, Willis EA, Sherman JR, White DA, Donnelly JE. Exploring the effectiveness of an 18-month weight management intervention in adults with Down syndrome using propensity score matching. J Intellect Disabil Res. 2020 Mar;64(3):221–33. https://doi.org/10.1111/jir.12713
  • Neale N, Padilla C, Fonseca LM, Holland T, Zaman S. Neuroimaging, and other modalities to assess Alzheimer’s disease in Down syndrome. Neuroimage Clin. 2018;17:263–71. https://doi.org/10.1016/j.nicl.2017.10.022
  • Head E, Powell DK, Schmitt FA. Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis. Front Aging Neurosci. 2018 Jun 21;10. https://doi.org/10.3389/fnagi.2018.00191
  • Abalan F, Jouan A, Weerts MT, Solles C, Brus J, Sauneron MF. A study of digestive absorption in four cases of Down’s syndrome. Down’s syndrome, malnutrition, malabsorption, and Alzheimer’s disease. Med Hypotheses. 1990 Jan;31(1):35–8. https://doi.org/10.1016/0306-9877(90)90051-F
  • Chen CC, Spanò G, Edgin JO. The impact of sleep disruption on executive function in Down syndrome. Res Dev Disabil. 2013 Jun;34(6):2033–9. https://doi.org/10.1016/j.ridd.2013.03.009
  • Chen CC, Ringenbach SDR, Crews D, Kulinna PH, Amazeen EL. The association between a single bout of moderate physical activity and executive function in young adults with Down syndrome: A preliminary study. Journal of Intellectual Disability Research. 2015 Jul 1;59(7):589–98. https://doi.org/10.1111/jir.12163
  • Chen CC, Ringenbach SDR. Dose-response relationship between intensity of exercise and cognitive performance in individuals with Down syndrome: A preliminary study. Journal of Intellectual Disability Research. 2016 Jun 1;60(6):606–14. https://doi.org/10.1111/jir.12258
  • Ptomey LT, Szabo AN, Willis EA, Gorczyca AM, Greene JL, Danon JC, et al. Changes in cognitive function after a 12-week exercise intervention in adults with Down syndrome. Disabil Health J. 2018 Jul;11(3):486–90. https://doi.org/10.1016/j.dhjo.2018.02.003
  • Pape SE, Baksh RA, Startin C, Hamburg S, Hithersay R, Strydom A. The Association between Physical Activity and CAMDEX-DS Changes Prior to the Onset of Alzheimer’s Disease in Down Syndrome. J Clin Med. 2021 Apr 27;10(9):1882. https://doi.org/10.3390/jcm10091882 preliminary study. Journal of Intellectual Disability Research. 2015 Jul 1;59(7):589–98. https://doi.org/10.1111/jir.12163