Respuesta autonómica e inflamatoria en obesos con resistencia a la insulina después de un entrenamiento de alta intensidad
- Alexis Espinoza-Salinas 1
- Luis Peiret-Villacura 1
- Igor Cigarroa-Cuevas 2
- Israel Podestá 3
- Sergio Acuña-Vera 1
- Giovanny Arenas-Sanchez 1
- Carlos Cristi-Montero 4
- Jose Gonáalez-Jurado 5
- 1 Universidad Santo Tomás - Santiago
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2
Universidad Católica Silva Henríquez
info
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3
University of Birmingham
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4
Pontificia Universidad Católica de Valparaíso
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5
Universidad Pablo de Olavide
info
ISSN: 1579-1726, 1988-2041
Any de publicació: 2025
Número: 62
Pàgines: 251-258
Tipus: Article
Altres publicacions en: Retos: nuevas tendencias en educación física, deporte y recreación
Resum
La obesidad es vinculada a una inflamación crónica que altera no sólo los marcadores inflamatorios sino también al sistema nervioso autonómico, estableciendo una predominancia simpática conduciendo aun riesgo cardiovascular. De esa manera el entrena-miento cardiovagal es reconocido un tratamiento que no sólo modifica la condición física sino también responde a regular el sistema autonómico y a los marcadores inflamatorios. El objetivo de este estudio fue analizar los resultados de un entrenamiento cardiovagal de 8 semanas valorando la respuesta autonómica, inflamatorios y metabólicas en obesos. Un total de 28 participantes con obesidad fueron estratificados según su HOMA-IR, el grupo sin resistencia a la insulina (NIR) y grupo con resistencia a la insulina (IR). Los participantes se sometieron a un entrenamiento cardiovagal durante 8 semanas. Se consideraron variables metabólicas como la insulina, leptina, TNFa, IL6 y el índice HOMA-IR como también variables de la variabilidad de la frecuencia cardíaca (VFC). Los resultados muestran que en las diferencias de cambio entre el pre y post intervención de los marcadores inflamatorios representaron cambios favorables en IL10 (NIR -0,21 y IR -0,45 pg/ml) y en TNFa (NIR -0,23 y IR -0,51 pg/mL). Mientras que en la VFC sus diferencias de cambio fueron favorables (p=>0,005) SDNN (NIR 3,17 y IR 17,32 ms), RMSSD (NIR 11,45 y IR 23,27 ms) y en LF/HF ratio (NIR 0,74 y IR 2,25 Hz). Se concluye que después de 8 semanas de intervención, el entrenamiento cardiovagal en personas obesas con RI aumentó la modulación parasimpática y atenuó los marcadores inflamatorios.
Referències bibliogràfiques
- Acosta B, A. M., Escalona O, M., Maiz G, A., Pollak C, F., & Leighton P, F. (2002). Determinación del índice de resis-tencia insulínica mediante HOMA en una población de la Región Metropolitana de Chile. Revista Medica de Chile, 130(11). doi.org/10.4067/s0034-98872002001100004
- Araújo, C. G., Castro, C. L., Franca, J. F., & Ramos, P. S. (2015). 4-Second Exercise Test: Reference Values for Ages 18-81 Years. Arquivos Brasileiros de Cardiologia, 104(5). https://doi.org/10.5935/abc.20150026
- Besnier, F., Labrunée, M., Pathak, A., Pavy-Le, T. A., Galès, C., Sénard, J. M., & Guiraud, T. (2017). Exercise train-ing-induced modification in autonomic nervous system: An update for cardiac patients. Annals of Physical and Rehabili-tation Medicine, 60(1). doi.org/10.1016/j.rehab.2016.07.002
- Besnier, F., Labrunée, M., Richard, L., Faggianelli, F., Kerros, H., Soukarié, L., Bousquet, M., Garcia, J. L., Pathak, A., Gales, C., Guiraud, T., & Sénard, J. M. (2019). Short-term effects of a 3-week interval training program on heart rate variability in chronic heart failure. A randomised controlled trial. Annals of Physical and Rehabilitation Medicine, 62(5). doi.org/10.1016/j.rehab.2019.06.013
- Cheema, B. S., Davies, T. B., Stewart, M., Papalia, S., & Atlantis, E. (2015). The feasibility and effectiveness of high-intensity boxing training versus moderate-intensity brisk walking in adults with abdominal obesity: a pilot study. BMC Sports Science, Medicine and Rehabilitation, 7. doi.org/10.1186/2052-1847-7-3
- Cuevas, N., Salamanca, A., Rodríguez-Romero, N., Weisstaub, G., Campos, R. R., & Rodríguez-Núñez, I. (2023). Autonomic dysfunction during the rest-to-exercise transition in obese children. Archivos de Cardiología de México, 93(2), 256.
- Dávila Grisalez, A. A., Mazuera Quiceno, C. A., Carreño Herrera, A. L., & Henao Corrales, J. L. (2020). Efecto de un programa de entrenamiento interválico aeróbico de alta intensidad en población escolar femenina con sobrepeso u obesidad (Effect of a high intensity aerobic interval training program on an overweight or obese female school popu-lation). Retos Digital, 39, 453–458.
- Dias, R. M., Moraes, Í. A. P., Mtap, D., Dcgl, F., Amgg, F., Silveira, A. C., Barnabé, V., Fernandes, M., Martinelli, P. M., Monteiro, C. B. M., Garner, D. M., Abreu, L. C., & Silva, T. D. (2021). Influence of Chronic Exposure to Ex-ercise on Heart Rate Variability in Children and Adolescents Affected by Obesity: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 18(21). doi.org/10.3390/ijerph182111065
- Duarte, C., Castro, C., & Araujo, C. (2013). Treinamento para disfunção vagal cardíaca com repetições da transição repouso-exercício. Revista Brasileira de Atividade Física & Saúde, 18(06). doi.org/10.12820/rbafs.v.18n6p688
- Dun, Y., Smith, J. R., Liu, S., & Olson, T. P. (2019). High-Intensity Interval Training in Cardiac Rehabilitation. Clinics in Geriatric Medicine, 35(4), 469–487.
- Endalifer, M. L., & Diress, G. (2020). Epidemiology, Predisposing Factors, Biomarkers, and Prevention Mechanism of Obesity: A Systematic Review. Journal of Obesity, 2020, 6134362.
- Espinoza-Salinas, A., González-Jurado, J., Burdiles-Alvarez, A., Arenas-Sanchez, G., & Bobadilla, M. (2019). Efectos del entrenamiento cardiovagal en la respuesta autonómica en personas con sobrepeso (Effects of cardiovagal training on autonomic response in overweight people). Retos Digital, 38, 118–122.
- Izzatunnisa, N., Hakim, F. A., Putra, W. M. I., Rejeki, P. S., Herawati, L., Novida, H., Halim, S., & Pranoto, A. (2024). Moderate-Intensity exercise has most beneficial effect on inflammatory response in fructose-induced mice (Mus musculus). Retos Digital, 60, 552–560.
- Frühbeck, G., Catalán, V., Rodríguez, A., & Gómez-Ambrosi, J. (2018). Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk. Adipocyte, 7(1). doi.org/10.1080/21623945.2017.1402151
- González-Jurado, J. A., Suárez-Carmona, W., López, S., & Sánchez-Oliver, A. J. (2020). Changes in Lipoinflammation Markers in People with Obesity after a Concurrent Training Program: A Comparison between Men and Women. In-ternational Journal of Environmental Research and Public Health, 17(17). doi.org/10.3390/ijerph17176168
- Hejazi, K., & Wong, A. (2023). Effects of exercise training on inflammatory and cardiometabolic health markers in overweight and obese adults: a systematic review and meta-analysis of randomized controlled trials. The Journal of Sports Medicine and Physical Fitness, 63(2). doi.org/10.23736/S0022-4707.22.14103-4
- Johnston, E. K., & Abbott, R. D. (2023). Adipose Tissue Paracrine-, Autocrine-, and Matrix-Dependent Signaling during the Development and Progression of Obesity. Cells , 12(3). doi.org/10.3390/cells12030407
- Khalafi, M., & Symonds, M. E. (2020). The impact of high-intensity interval training on inflammatory markers in meta-bolic disorders: A meta-analysis. Scandinavian Journal of Medicine & Science in Sports, 30(11). doi.org/10.1111/sms.13754
- Kurtoğlu, S., Hatipoğlu, N., Mazıcıoğlu, M., Kendirici, M., Keskin, M., & Kondolot, M. (2010). Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods. Journal of Clinical Research in Pediatric Endocrinology, 2(3). doi.org/10.4274/jcrpe.v2i3.100
- Lee, J. (2020). Influences of Cardiovascular Fitness and Body Fatness on the Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis. American Journal of Health Promotion: AJHP, 34(7). doi.org/10.1177/0890117120925347
- Merkow, R. P., Kaji, A. H., & Itani, K. M. F. (2021). Reporting Guidelines: The Consolidated Standards of Reporting Trials (CONSORT) Framework. JAMA Surgery, 156(9), 877.
- Mohammadian Khonsari, N., Baygi, F., Tabatabaei-Malazy, O., Mohammadpoor Nami, S., Ehsani, A., Asadi, S., & Qor-bani, M. (2023). Association of normal weight obesity phenotype with inflammatory markers: A systematic review and meta-analysis. Frontiers in Immunology, 14, 1044178.
- O’Donoghue, G., Blake, C., Cunningham, C., Lennon, O., & Perrotta, C. (2021). What exercise prescription is opti-mal to improve body composition and cardiorespiratory fitness in adults living with obesity? A network meta-analysis. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity, 22(2). doi.org/10.1111/obr.13137
- Olateju, I. V., Opaleye-Enakhimion, T., Udeogu, J. E., Asuquo, J., Olaleye, K. T., Osa, E., & Oladunjoye, A. F. (2023). A systematic review on the effectiveness of diet and exercise in the management of obesity. Diabetes & Metabolic Syn-drome, 17(4). doi.org/10.1016/j.dsx.2023.102759
- Perrotta, A. S., Jeklin, A. T., Hives, B. A., Meanwell, L. E., & Warburton, D. E. R. (2017). Validity of the Elite HRV Smartphone Application for Examining Heart Rate Variability in a Field-Based Setting. Journal of Strength and Condi-tioning Research / National Strength & Conditioning Association, 31(8). doi.org/10.1519/JSC.0000000000001841
- Quarti, T. F., Dell’Oro, R., Biffi, A., Seravalle, G., Corrao, G., Mancia, G., & Grassi, G. (2020). Sympathetic overdrive in the metabolic syndrome: meta-analysis of published studies. Journal of Hypertension, 38(4). doi.org/10.1097/HJH.0000000000002288
- Raffin, J., Barthélémy, J. C., Dupré, C., Pichot, V., Berger, M., Féasson, L., Busso, T., Da Costa, A., Colvez, A., Montuy-Coquard, C., Bouvier, R., Bongue, B., Roche, F., & Hupin, D. (2019). Exercise Frequency Determines Heart Rate Variability Gains in Older People: A Meta-Analysis and Meta-Regression. Sports Medicine , 49(5). doi.org/10.1007/s40279-019-01097-7
- Regina de Sousa, T., Gabriel da Silva Alexandrino, W., Souza, A., Faundez-Casanova, C., Jane dos Santos Pascoini, M., Andréia Mochi Awada, M., De Paula, R., Merchan Ferraz Grizzo, F., Oltramari, K., Westphal-Nardo, G., & Nardo Junior, N. (2024). Effects of physical activity in adults with severe obesity: a systematic review. Retos Digital, 53, 671–680.
- Rossi, R. C., Vanderlei, L. C., Gonçalves, A. C., Vanderlei, F. M., Bernardo, A. F., Yamada, K. M., da Silva, N. T., & de Abreu, L. C. (2015). Impact of obesity on autonomic modulation, heart rate and blood pressure in obese young people. Autonomic Neuroscience: Basic & Clinical, 193. doi.org/10.1016/j.autneu.2015.07.424
- Rumbo-Rodríguez, L., Sánchez-SanSegundo, M., Ferrer-Cascales, R., García-D’Urso, N., Hurtado-Sánchez, J. A., & Zaragoza-Martí, A. (2021). Comparison of Body Scanner and Manual Anthropometric Measurements of Body Shape: A Systematic Review. International Journal of Environmental Research and Public Health, 18(12). doi.org/10.3390/ijerph18126213
- Sánchez-Otero, T., Tuimil, J. L., Boullosa, D., Varela-Sanz, A., & Iglesias-Soler, E. (2022). Active vs. passive recovery during an aerobic interval training session in well-trained runners. European Journal of Applied Physiology, 122(5), 1281.
- Santos, C. C., Diniz, T. A., Inoue, D. S., Gerosa-Neto, J., Panissa, V. L. G., Pimentel, G. D., Campos, E. Z., Hofmann, P., & Lira, F. S. (2016). Influence to high-intensity intermittent and moderate-intensity continuous exercise on indi-ces of cardio-inflammatory health in men. European Journal of Cardiovascular Prevention and Rehabilitation: Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 12(6), 618.
- Saxton, S. N., Clark, B. J., Withers, S. B., Eringa, E. C., & Heagerty, A. M. (2019). Mechanistic Links Between Obesi-ty, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue. Physiological Reviews, 99(4). doi.org/10.1152/physrev.00034.2018
- Saxton, S. N., Withers, S. B., & Heagerty, A. M. (2019). Emerging Roles of Sympathetic Nerves and Inflammation in Perivascular Adipose Tissue. Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy, 33(2), 245.
- Schlaich, M., Straznicky, N., Lambert, E., & Lambert, G. (2015). Metabolic syndrome: a sympathetic disease? The Lan-cet. Diabetes & Endocrinology, 3(2). doi.org/10.1016/S2213-8587(14)70033-6
- Sember, V., Meh, K., Sorić, M., Starc, G., Rocha, P., & Jurak, G. (2020). Validity and Reliability of International Physi-cal Activity Questionnaires for Adults across EU Countries: Systematic Review and Meta Analysis. International Jour-nal of Environmental Research and Public Health, 17(19). doi.org/10.3390/ijerph17197161
- Shaffer, F., & Ginsberg, J. P. (2017). An Overview of Heart Rate Variability Metrics and Norms. Frontiers in Public Health, 5, 290215.
- Silva, L. R. B., Gentil, P. R. V., Beltrame, T., Basso Filho, M. A., Alves, F. M., Silva, M. S., Pedrino, G. R., Ramirez-Campillo, R., Coswig, V., & Rebelo, A. C. S. (2019). Exponential model for analysis of heart rate responses and au-tonomic cardiac modulation during different intensities of physical exercise. Royal Society Open Science, 6(10), 190639.
- Sirico, F., Bianco, A., D’Alicandro, G., Castaldo, C., Montagnani, S., Spera, R., Di Meglio, F., & Nurzynska, D. (2018). Effects of Physical Exercise on Adiponectin, Leptin, and Inflammatory Markers in Childhood Obesity: Systematic Review and Meta-Analysis. Childhood Obesity , 14(4). doi.org/10.1089/chi.2017.0269
- Strüven, A., Holzapfel, C., Stremmel, C., & Brunner, S. (2021). Obesity, Nutrition and Heart Rate Variability. Interna-tional Journal of Molecular Sciences, 22(8). doi.org/10.3390/ijms22084215
- Vosseler, A., Machann, J., Fritsche, L., Prystupa, K., Kübler, C., Häring, H. U., Birkenfeld, A. L., Stefan, N., Peter, A., Fritsche, A., Wagner, R., & Heni, M. (2022). Interscapular fat is associated with impaired glucose tolerance and insulin resistance independent of visceral fat mass. Obesity , 30(11). doi.org/10.1002/oby.23554
- Wang, T., & He, C. (2018). Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine & Growth Factor Reviews, 44. https://doi.org/10.1016/j.cytogfr.2018.10.002
- Wang, S., Zhou, H., Zhao, C., & He, H. (2022). Effect of Exercise Training on Body Composition and Inflammatory Cytokine Levels in Overweight and Obese Individuals: A Systematic Review and Network Meta-Analysis. Frontiers in Immunology, 13. doi.org/10.3389/fimmu.2022.921085
- Wewege, M., van den Berg, R., Ward, R. E., & Keech, A. (2017). The effects of high-intensity interval training vs. moderate-intensity continuous training on body composition in overweight and obese adults: a systematic review and meta-analysis. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity, 18(6). doi.org/10.1111/obr.12532
- White, D. W., & Raven, P. B. (2014). Autonomic neural control of heart rate during dynamic exercise: revisited. The Journal of Physiology, 592(12), 2491–2500.
- Wu, H., & Ballantyne, C. M. (2017). Skeletal muscle inflammation and insulin resistance in obesity. The Journal of Clinical Investigation, 127(1), 43–54.
- Zhang, S., Huang, Y.-P., Li, J., Wang, W.-H., Zhang, M.-Y., Wang, X.-C., Lin, J.-N., & Li, C.-J. (2022). The Visceral-Fat-Area-to-Hip-Circumference Ratio as a Predictor for Insulin Resistance in a Chinese Population with Type 2 Dia-betes. Obesity Facts, 15(4), 621–628.