Javier
López-Ríos Moreno
Publicaciones (32) Publicaciones de Javier López-Ríos Moreno
2024
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Increased enhancer–promoter interactions during developmental enhancer activation in mammals
Nature Genetics, Vol. 56, Núm. 4, pp. 675-685
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The cellular landscape of the endochondral bone during the transition to extrauterine life
Immunology and Cell Biology, Vol. 102, Núm. 2, pp. 131-148
2023
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Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1
Journal of Biological Chemistry, Vol. 299, Núm. 8
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The little skate genome and the evolutionary emergence of wing-like fins
Nature, Vol. 616, Núm. 7957, pp. 495-503
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Topologically associating domain boundaries are required for normal genome function
Communications Biology, Vol. 6, Núm. 1
2021
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Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
Nature Communications, Vol. 12, Núm. 1
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The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Núm. 46
2020
2018
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Enhancer redundancy provides phenotypic robustness in mammalian development
Nature, Vol. 554, Núm. 7691, pp. 239-243
2017
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HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development
Cell Reports, Vol. 19, Núm. 8, pp. 1602-1613
2016
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Progressive Loss of Function in a Limb Enhancer during Snake Evolution
Cell, Vol. 167, Núm. 3, pp. 633-642.e11
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The many lives of SHH in limb development and evolution
Seminars in Cell and Developmental Biology, Vol. 49, pp. 116-124
2014
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Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs
Nature, Vol. 511, Núm. 7507, pp. 46-51
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HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme
Developmental Cell, Vol. 31, Núm. 3, pp. 345-357
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Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium
Cell Reports, Vol. 9, Núm. 6, pp. 2071-2083
2012
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Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds
BMC Developmental Biology, Vol. 12
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GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis
Developmental Cell, Vol. 22, Núm. 4, pp. 837-848
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Sensing BMP pathway activity by immune detection of phosphorylated r-smad proteins in mouse embryonic kidney
Methods in Molecular Biology, Vol. 886, pp. 267-273
2010
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Dual RMCE for efficient re-engineering of mouse mutant alleles
Nature Methods, Vol. 7, Núm. 11, pp. 893-895
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Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development
BMC Developmental Biology, Vol. 10