Respuesta de schizosaccharomyces pombe a la desestabilización de microtúbulos interfásicos

  1. Fernando Romero Balestra
Supervised by:
  1. Juan Jiménez Director

Defence university: Universidad Pablo de Olavide

Year of defence: 2009

  1. Jaime Correa Bordes Chair
  2. Rafael Daga Secretary
  3. José Cansado Vizoso Committee member
  4. Juan Ignacio Mata Monteagudo Committee member
  5. María de la Cruz Muñoz Centeno Committee member
  1. Molecular Biology and Biochemical Engineering

Type: Thesis

Teseo: 303789 DIALNET


Microtubules assume a variety of structures throughout the different stages of the cell cycle. Ensuring the correct assembly of such structures is essential to guarantee cell division. During mitosis, it is well established that the spindle assembly checkpoint monitors the correct attachment of sister chromatids to the mitotic spindle. However, the role that microtubule cytoskeleton integrity plays for cell-cycle progression during interphase is uncertain. Here we describe the existence of a mechanism, independent of the mitotic checkpoint, that delays entry into mitosis in response to G(2)-phase microtubule damage. Disassembly of the G(2)-phase microtubule array leads to the stabilization of the universal mitotic inhibitor Wee1, thus actively delaying entry into mitosis via inhibitory Cdc2 Tyr15 phosphorylation.