Minor components of pomace olive oil enhance VLDL-receptor expression in macrophages when treated with postprandial triglyceride-rich lipoproteins

  1. R. Cabello-Moruno 1
  2. L. Sinausia 1
  3. E. Montero 2
  4. K.M. Botham 3
  5. M. Avella 3
  6. J.S. Perona 4
  1. 1 Universidad Pablo de Olavide, Seville, Spain
  2. 2 General Hospital. HHUU Virgen del Rocío, Seville, Spain
  3. 3 The Royal Veterinary College, London, United Kingdom
  4. 4 Universidad Pablo de Olavide, Seville
Erakutsi afiliazioak +
Aldizkaria:
Grasas y aceites

ISSN: 0017-3495,  1988-4214

Argitalpen urtea: 2015

Alea: 66

Zenbakia: 4

Mota: Artikulua

DOI: 10.3989/GYA.0109151 DIALNET GOOGLE SCHOLAR lock_openSarbide irekia editor

Beste argitalpen batzuk: Grasas y aceites

Laburpena

Pomace olive oil (POO) is rich in minor components, which can modulate the composition of postprandial triglyceride-rich lipoproteins (TRL) and their uptake by macrophages. The aim of the present study was to investigate the effects of postprandial TRL obtained after the ingestion of meals containing POO or refined olive oil (ROO) on foam cell formation, one of the initial steps of atherogenesis. Meals were administered to 9 healthy men and TRL were isolated from serum 4h after the intake. POO intake led to TRL with lower triglyceride/apo B48 and triglyceride/apo B100 ratios compared to ROO. Upon incubation of THP-1 macrophages with the TRL, an increase in the intracellular triglyceride content and foam cell formation was observed. Compared to ROO-TRL, the only receptor involved in lipoprotein uptake that showed changes in the mRNA expression after treatment with POO-TRL was the VLDL-receptor (VLDLr). In conclusion, the intake of POO modified the composition of human TRL, which increased the VLDLr gene expression in macrophages. However, the changes were not sufficient to enhance foam cell formation.

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