A Mediterranean-style breakfast increases postprandial serum α-tocopherol levels in lean and obese individuals

  1. García-Rodríguez, S.
  2. Sinausia, L.
  3. Barragán, C.
  4. Montero, E.
  5. Perona, J. S.
Revista:
Grasas y aceites

ISSN: 0017-3495 1988-4214

Año de publicación: 2018

Volumen: 69

Número: 3

Tipo: Artículo

DOI: 10.3989/GYA.1225172 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Grasas y aceites

Resumen

El objetivo de este estudio fue comparar las variaciones en la concentración de tocoferoles y retinol en adultos obesos en el estado postprandial tras la ingesta de un desayuno mediterráneo u occidental. Consiste en un ensayo de intervención aleatorio y controlado, en el que participaron 24 adultos varones (12 obesos y 12 normopeso). Tras la ingesta de dichas comidas, se determinaron las concentraciones de α-tocoferol, γ-tocoferol y retinol en el suero de las muestras sanguíneas mediante HPLC. La comida de estilo mediterráneo aumentó los niveles séricos de α-tocoferol en sujetos obesos y de peso normal, en comparación con una comida de estilo occidental, lo que indica que la composición del alimento afecta a su concentración sérica. Sin embargo, referente al γ-tocoferol y retinol, permanecieron sin modificaciones. En conclusión, la presencia de α-tocoferol en una comida de estilo mediterráneo podría contribuir a la protección contra la aterosclerosis en el estado postprandial.

Información de financiación

This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness under Grant AGL2011-23810.

Financiadores

Referencias bibliográficas

  • Amigo-Benavent M, Sinausia L, Montero E, Perona JS. 2016. Discordant ability of the triglyceride to apolipoprotein B ratio to predict triglyceride-rich lipoprotein particle size in normal-weight and obese men. Exp. Biol. Med. 241, 1772–1775.
  • Armengol Lopez S, Botham KM, Lawson C. 2012. The oxidative state of chylomicron remnants influences their modulation of human monocyte activation. Int. J. Vasc. Med. 2012.
  • Ascherio A, Stampfer MJ, Colditz GA, Rimm EB, Litin L, Willett WC. 1992. Correlations of vitamin A and E intakes with the plasma concentrations of carotenoids and tocopherols among American men and women. J. Nutr. 122, 1792–1801.
  • Bach-Faig A, Geleva D, Carrasco J, Ribas-Barba L, Serra- Majem L. 2006. Evaluating associations between Mediterranean diet adherence indexes and biomarkers of diet and disease. Public. Health Nutr. 9, 1110–1117.
  • Bates CJ, Mishra GD, Prentice A. 2004. ?-Tocopherol as a possible marker for nutrition-related risk: results from four National Diet and Nutrition Surveys in Britain. Br. J. Nutr. 92, 137.
  • Cabello-Moruno R, Perona JS, Ruiz-Gutierrez V. 2007. Influence of minor components of olive oils on the composition and size of TRLs and on macrophage receptors involved in foam cell formation. Biochem. Soc. Trans. 35, 470–471.
  • Cabello-Moruno R, Sinausia L, Botham KM, Montero E, Avella M, Perona JS. 2014. Postprandial phase time influences the uptake of TAG from postprandial TAG-rich lipoproteins by THP-1 macrophages. Br. J. Nutr. 112, 1469–1477.
  • Carnevale R, Pignatelli P, Nocella C, Loffredo L, Pastori D, Vicario T, Petruccioli A, Bartimoccia S, Violi F. 2014. Extra virgin olive oil blunt post-prandial oxidative stress via NOX2 down-regulation. Atherosclerosis. 235, 649–658.
  • Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge. Clin. Chem. 18, 499–502.
  • Fuhrman B, Volkova N, Rosenblat M, Aviram M. 2000. Lycopene Synergistically Inhibits LDL Oxidation in Combination with Vitamin E, Glabridin, Rosmarinic Acid, Carnosic Acid, or Garlic. Antioxidants & Redox Signaling 2, 491–506.
  • Godbout J, Berg BM, Kelley KW, Johnson RW. 2004. ?-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain. J. Neuroimmunol. 149, 101–109.
  • Guerci B, Vergès B, Durlach V, Hadjadj S, Drouin P, Paul JL. 2000. Relationship between altered postprandial lipemia and insulin resistance in normolipidemic and normoglucose tolerant obese patients. Int. J. Obes. Relat. Metab. Disord. 24, 468–478.
  • Hak AE, Stampfer MJ, Campos H, Sesso HD, Gaziano JM, Willett W, Ma J. 2003. Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians. Circulation 108, 802–807.
  • Hoydonck PGA van, Schouten EG, Manuel-y-Keenoy B, Campenhout A van, Hoppenbrouwers KPM, Temme EHM. 2004. Does vitamin C supplementation influence the levels of circulating oxidized LDL, sICAM-1, sVCAM-1 and vWF-antigen in healthy male smokers? Eur. J. Clin. Nutr. 58, 1587–1593.
  • Mah E, Noh SK, Ballard KD, Park HJ, Volek JS, Bruno RS. 2013. Supplementation of a ?-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia. J. Nutr. Biochem. 24, 196–203.
  • Majerczyk M, Olszanecka-glinianowicz M, Puzianowska- M, Chudek J. 2016. Retinol-binding protein 4 (RBP4) as the causative factor and marker of vascular injury related to insulin resistance. Postepy. Hig. Med. Dosw. 70, 1267–1275.
  • Manuel-Y-Keenoy B, Campenhout A van, Vertommen J, Gaal L van, De Leeuw I. 2004. Evolution of serum ?-tocopherol in the postprandial and postabsorptive phases in type 1 diabetes mellitus. Ann. N. Y. Acad. Sci. 1031, 439–442. https://doi.org/10.1196/annals.1331.067
  • Maruyama C, Kikuchi N, Masuya Y, Hirota S, Araki R, Maruyama T. 2013. Effects of green-leafy vegetable intake on postprandial glycemic and lipidemic responses and ?-tocopherol concentration in normal weight and obese men. J. Nutr. Sci. Vitaminol. 59, 264–271.
  • Mody N. 2017. Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance. Proc. Nutr. Soc. 76, 597–602.
  • Nielsen NS, Marckmann P, Høy C. 2000. Effect of meal fat quality on oxidation resistance of postprandial VLDL and LDL particles and plasma triacylglycerol level. Br. J. Nutr. 84, 855–863.
  • Plotnick GD, Corretti MC, Vogel RA. 1997. Effect of Antioxidant Vitamins on the Transient Impairment of Endothelium—Dependent Brachial Artery Vasoactivity Following a Single High-Fat Meal. JAMA J. Am. Med. Assoc. 278, 1682–1686.
  • Spanish Agency for Consumer Affairs, Food Safety and Nutrition A. Spanish database of food composition. http:// www.bedca.net/bdpub/index.php. Accessed 11-29-2017.
  • Teupser D, Thiery J, Seidel D. 1999. Alpha-tocopherol down-regulates scavenger receptor activity in macrophages. Atherosclerosis 144, 109–115.
  • Traber MG, Leonard SW, Bobe G, Fu X, Saltzman E, Grusak MA, Booth SL. 2015. ?-tocopherol disappearance rates from plasma depend on lipid concentrations: Studies using deuterium-labeled collard greens in younger and older adults. Am. J. Clin. Nutr. 101, 752–759.
  • Traber MG, Mah E, Leonard SW, Bobe G, Bruno RS. 2017. Metabolic syndrome increases dietary alpha-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial. Am. J. Clin. Nutr. 105, 571–579.
  • Trpkovic A, Resanovic I, Stanimirovic J, Radak D, Mousa SA, Cenic-Milosevic D, Jevremovic D, Isenovic ER. 2015. Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases. Crit. Rev. Clin. Lab. Sci. 52, 70–85.
  • Uzun A, Yener U, Cicek OF, Yener O, Yalcinkaya A, Diken A, Ozkan T, Turkvatan A, Ulas M. 2013. Does vitamin C or its combination with vitamin E improve radial artery endothelium-dependent vasodilatation in patients awaiting coronary artery bypass surgery? Cardiovasc. J. Afr. 24, 255–259.