Bone mineral density in anorexia nervosaonly weight and menses recovery?

  1. Ignacio Jáuregui-Lobera 1
  2. Patricia Bolaños Ríos 2
  3. Juan Sabaté Diaz 3
  1. 1 Universidad Pablo de Olavide. Departamento de Biología Molecular e Ingeniería Bioquímica
  2. 2 Instituto de Ciencias de la Conducta
  3. 3 Universidad de Sevilla

    Universidad de Sevilla

    Sevilla, España


Endocrinología y nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición

ISSN: 1575-0922

Year of publication: 2016

Volume: 63

Issue: 9

Pages: 458-465

Type: Article


More publications in: Endocrinología y nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición


Cited by

  • Scopus Cited by: 5 (15-01-2024)
  • Web of Science Cited by: 4 (15-10-2023)
  • Dimensions Cited by: 6 (15-12-2023)

JCR (Journal Impact Factor)

  • Year 2016
  • Journal Impact Factor: 1.106
  • Journal Impact Factor without self cites: 0.982
  • Article influence score: 0.0
  • Best Quartile: Q4
  • Area: NUTRITION & DIETETICS Quartile: Q4 Rank in area: 64/81 (Ranking edition: SCIE)
  • Area: ENDOCRINOLOGY & METABOLISM Quartile: Q4 Rank in area: 127/138 (Ranking edition: SCIE)


(Data updated as of 15-12-2023)
  • Total citations: 6
  • Recent citations (2 years): 0
  • Relative Citation Ratio (RCR): 0.19
  • Field Citation Ratio (FCR): 1.53


Introduction The study objectives were to analyze the presence of reduced bone mass in a sample of patients with anorexia nervosa (AN) and amenorrhea, to assess Bone Mineral Density (BMD) recovery after having a normal weight is reached and regular menses are resumed, and to predict BMD after a treatment period considering different variables (baseline BMD, baseline and final body mass index (BMI), treatment duration). Material & Methods 35 patients with AN (mean age 20.57 ± 5.77) were studied at treatment start (T0) and after they had recovered their normal weight and regular menses (T1) in order to measure their BMD using quantitative computed tomography (QCT) of the lumbar spine (L2–L4). Results At T0, 2.86% of patients had normal BMD, while a reduced bone mass consistent with osteopenia or with osteoporosis was found in 22.86% and 74.28% of patients respectively. At T1, the percentages were 20%, 20%, and 60% respectively. No significant differences were seen in L2–L3 and mean BMD (L2–L4). A significant difference was however found for L4 (p < 0.05). A positive relationship was seen between final body mass index (BMI) and final BMD in patients with T0–T1 > 11 months, but not when the time period was ≤11 months. Conclusions This follow-up study of changes not only in BMD but also in BMI and recovery of menses has clinical relevance from the viewpoint of the day-by-day treatment process. Use of QCT makes the study more relevant because this is a more advanced technique that allows for differentiating trabecular and cortical bone.